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Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

Schröder, Christopher, Leitão, Elsa, Wallner, Stefan, Schmitz, Gerd, Klein-Hitpass, Ludger, Sinha, Anupam, Jöckel, Karl-Heinz, Heilmann-Heimbach, Stefanie , Hoffmann, Per, Nöthen, Markus M., Steffens, Michael, Ebert, Peter , Rahmann, Sven and Horsthemke, Bernhard (2017) Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function. Epigenetics & Chromatin 10 (1).

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Other URL: http://doi.org/10.1186/s13072-017-0144-2

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Abstract

Background: There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin
Identification Number:
ValueType
10.1186/s13072-017-0144-2DOI
Keywords:HEINZ NIXDORF RECALL; HUMAN EPIGENOME; GENOME; DISEASE; TRANSCRIPTION; CHROMATIN; STRINGTIE; ALIGNMENT; DATABASE; VARIANTS; DNA methylation; Haplotype; Genome-wide association study; Differentially methylated regions; Inter-individual variability; Allele-specific methylation; Whole genome bisulfite sequencing; SNP genotyping; Methylation array
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39351
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