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Regions of common inter-individual DNA methylation differences in human monocytes: genetic basis and potential function

Schröder, Christopher ; Leitão, Elsa ; Wallner, Stefan ; Schmitz, Gerd ; Klein-Hitpass, Ludger ; Sinha, Anupam ; Jöckel, Karl-Heinz ; Heilmann-Heimbach, Stefanie ; Hoffmann, Per ; Nöthen, Markus M. ; Steffens, Michael ; Ebert, Peter ; Rahmann, Sven ; Horsthemke, Bernhard



Abstract

Background: There is increasing evidence for inter-individual methylation differences at CpG dinucleotides in the human genome, but the regional extent and function of these differences have not yet been studied in detail. For identifying regions of common methylation differences, we used whole genome bisulfite sequencing data of monocytes from five donors and a novel bioinformatic strategy. ...

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