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Molecular mechanisms of Bdp1 in TFIIIB assembly and RNA polymerase III transcription initiation

Gouge, Jerome ; Guthertz, Nicolas ; Kramm, Kevin ; Dergai, Oleksandr ; Abascal-Palacios, Guillermo ; Satia, Karishma ; Cousin, Pascal ; Hernandez, Nouria ; Grohmann, Dina ; Vannini, Alessandro



Abstract

Initiation of gene transcription by RNA polymerase (Pol) III requires the activity of TFIIIB, a complex formed by Brf1 (or Brf2), TBP (TATA-binding protein), and Bdp1. TFIIIB is required for recruitment of Pol III and to promote the transition from a closed to an open Pol III pre-initiation complex, a process dependent on the activity of the Bdp1 subunit. Here, we present a crystal structure of a ...

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