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Lymphatic Endothelial Cells Control Initiation of Lymph Node Organogenesis

Onder, Lucas ; Mörbe, Urs ; Pikor, Natalia ; Novkovic, Mario ; Cheng, Hung-Wei ; Hehlgans, Thomas ; Pfeffer, Klaus ; Becher, Burkhard ; Waisman, Ari ; Rülicke, Thomas ; Gommerman, Jennifer ; Mueller, Christopher G. ; Sawa, Shinichiro ; Scandella, Elke ; Ludewig, Burkhard



Abstract

Lymph nodes (LNs) are strategically situated throughout the body at junctures of the blood vascular and lymphatic systems to direct immune responses against antigens draining from peripheral tissues. The current paradigm describes LN development as a programmed process that is governed through the interaction between mesenchymal lymphoid tissue organizer (LTo) cells and hematopoietic lymphoid ...

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