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FOXM1 predicts overall and disease specific survival in muscle-invasive urothelial carcinoma and presents a differential expression between bladder cancer subtypes

Rinaldetti, Sebastien ; Wirtz, Ralph Markus ; Worst, Thomas Stefan ; Eckstein, Markus ; Weiss, Cleo Aaron ; Breyer, Johannes ; Otto, Wolfgang ; Bolenz, Christian ; Hartmann, Arndt ; Erben, Philipp



Abstract

Forkhead box M1 (FOXM1) is a late cell cycle gene that plays a crucial role in carcinogenesis and chemotherapeutic drug resistance. In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naive muscle-invasive bladder cancer (MIBC) patients. Expression analyses were performed on the ...

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