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Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor

Jeske, Judith, Bitter, Andreas, Thasler, Wolfgang E., Weiss, Thomas S. , Schwab, Matthias and Burk, Oliver (2017) Ligand-dependent and -independent regulation of human hepatic sphingomyelin phosphodiesterase acid-like 3A expression by pregnane X receptor and crosstalk with liver X receptor. Biochemical Pharmacology 136, pp. 122-135.

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Other URL: http://doi.org/10.1016/j.bcp.2017.04.013


Abstract

Pregnane X receptor (PXR) mainly regulates xenobiotic metabolism and detoxification. Additionally, it exerts pleiotropic effects on liver physiology, which in large parts depend on transrepression of other liver-enriched transcription factors. Based on the hypothesis that lower expression levels of PXR may reduce the extent of this inhibition, an exploratory genome-wide transcriptomic profiling ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
10.1016/j.bcp.2017.04.013DOI
Keywords:DRUG-METABOLIZING-ENZYMES; XENOBIOTIC RECEPTOR; RESPONSE ELEMENTS; HUMAN HEPATOCYTES; GENE-EXPRESSION; TARGET GENES; PPAR-ALPHA; PXR; BINDING; CAR; Pregnane X receptor; Liver X receptor; Hepatocytes; Gene regulation; Ligand-independent repression
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39364
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