Go to content
UR Home

Phosphorylation of Argonaute proteins affects mRNA binding and is essential for microRNA‐guided gene silencing in vivo

Quévillon Huberdeau, Miguel ; Zeitler, Daniela M. ; Hauptmann, Judith ; Bruckmann, Astrid ; Fressigné, Lucile ; Danner, Johannes ; Piquet, Sandra ; Strieder, Nicholas ; Engelmann, Julia C. ; Jannot, Guillaume ; Deutzmann, Rainer ; Simard, Martin J. ; Meister, Gunter



Abstract

Argonaute proteins associate with microRNAs and are key components of gene silencing pathways. With such a pivotal role, these proteins represent ideal targets for regulatory post-translational modifications. Using quantitative mass spectrometry, we find that a C-terminal serine/threonine cluster is phosphorylated at five different residues in human and Caenorhabditis elegans. In human, ...

plus


Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de
0941 943 4239

Dissertations: dissertationen@ur.de
0941 943 3904

Research data: daten@ur.de
0941 943 4239

Contact persons