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Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis

Dengler, Mirko, Staufer, Katharina, Huber, Heidemarie, Stauber, Rudolf, Bantel, Heike, Weiss, Karl Heinz , Starlinger, Patrick, Pock, Hannelore, Plachky, Petra Klöters-, Gotthardt, Daniel N., Rauch, Peter, Lackner, Carolin, Stift, Judith , Brostjan, Christine, Gruenberger, Thomas, Kumada, Takashi, Toyoda, Hidenori, Tada, Toshifumi, Weiss, Thomas S. , Trauner, Michael and Mikulits, Wolfgang (2017) Soluble Axl is an accurate biomarker of cirrhosis and hepatocellular carcinoma development: results from a large scale multicenter analysis. Oncotarget 8 (28).

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Other URL: http://doi.org/10.18632/oncotarget.17598


Abstract

Patients with chronic liver disease (CLD) and cirrhosis are at high risk for hepatocellular carcinoma (HCC). Current diagnostic tools for HCC detection include imaging techniques and serum biomarkers such as a-fetoprotein (AFP). Yet, these methods are limited in sensitivity and specificity to accurately detect early HCC. Here we focused on the potential of soluble Axl (sAxl) as a biomarker in CLD ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
10.18632/oncotarget.17598DOI
Keywords:SYSTEMIC-LUPUS-ERYTHEMATOSUS; DES-GAMMA-CARBOXYPROTHROMBIN; CHRONIC LIVER-DISEASE; KINASE RECEPTOR AXL; ALPHA-FETOPROTEIN; PLASMA-CONCENTRATIONS; TYROSINE KINASE; UNITED-STATES; PROTEIN; GAS6; soluble Axl; biomarker; fibrosis; cirrhosis; hepatocellular carcinoma
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39370
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