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Differential contribution of immune effector mechanisms to cortical demyelination in multiple sclerosis

Lagumersindez-Denis, Nielsen ; Wrzos, Claudia ; Mack, Matthias ; Winkler, Anne ; van der Meer, Franziska ; Reinert, Marie C. ; Hollasch, Heiko ; Flach, Anne ; Brühl, Hilke ; Cullen, Eilish ; Schlumbohm, Christina ; Fuchs, Eberhard ; Linington, Christopher ; Barrantes-Freer, Alonso ; Metz, Imke ; Wegner, Christiane ; Liebetanz, David ; Prinz, Marco ; Brück, Wolfgang ; Stadelmann, Christine ; Nessler, Stefan



Abstract

Cortical demyelination is a widely recognized hallmark of multiple sclerosis (MS) and correlate of disease progression and cognitive decline. The pathomechanisms initiating and driving gray matter damage are only incompletely understood. Here, we determined the infiltrating leukocyte subpopulations in 26 cortical demyelinated lesions of biopsied MS patients and assessed their contribution to ...

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