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Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation

Meyer-Roxlau, Stefanie, Lämmle, Simon, Opitz, Annett, Künzel, Stephan, Joos, Julius P., Neef, Stefan, Sekeres, Karolina, Sossalla, Samuel, Schöndube, Friedrich, Alexiou, Konstantin, Maier, Lars S., Dobrev, Dobromir, Guan, Kaomei , Weber, Silvio and El-Armouche, Ali (2017) Differential regulation of protein phosphatase 1 (PP1) isoforms in human heart failure and atrial fibrillation. Basic Research in Cardiology 112 (4).

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Other URL: http://doi.org/10.1007/s00395-017-0635-0


Abstract

Protein phosphatase 1 (PP1) is a key regulator of important cardiac signaling pathways. Dysregulation of PP1 has been heavily implicated in cardiac dysfunctions. Accordingly, pharmacological targeting of PP1 activity is considered for therapeutic intervention in human cardiomyopathies. Recent evidence from animal models implicated previously unrecognized, isoform-specific activities of PP1 in the ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1007/s00395-017-0635-0DOI
Keywords:ENDOPLASMIC-RETICULUM STRESS; SERINE/THREONINE PHOSPHATASES; CATALYTIC SUBUNITS; HYPERTROPHY; INHIBITION; EXPRESSION; DISEASE; MUSCLE; Protein phosphatase 1 (PP1) isoforms; Human heart failure; Atrial fibrillation; Beta-blocker; Endoplasmic reticulum stress response
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39419
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