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Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability

Neef, Stefan, Mann, Christian, Zwenger, Anne, Dybkova, Nataliya and Maier, Lars S. (2017) Reduction of SR Ca2+ leak and arrhythmogenic cellular correlates by SMP-114, a novel CaMKII inhibitor with oral bioavailability. Basic Research in Cardiology 112 (4).

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Other URL: http://doi.org/10.1007/s00395-017-0637-y


Abstract

Sarcoplasmic reticulum (SR) Ca2+ leak induced by Ca2+/calmodulin-dependent protein kinase II (CaMKII) is centrally involved in atrial and ventricular arrhythmogenesis as well as heart failure remodeling. Consequently, treating SR Ca2+ leak has been proposed as a novel therapeutic paradigm, but compounds for use in humans are lacking. SMP-114 ("Rimacalib'') is a novel, orally available CaMKII ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1007/s00395-017-0637-yDOI
Keywords:CHRONIC ATRIAL-FIBRILLATION; HEART-FAILURE; KINASE-II; PHOSPHORYLATION; STABILIZATION; CONTRACTILITY; ARRHYTHMIAS; PROGRESSION; POPULATION; MYOCARDIUM; Heart failure; Arrhythmias; SR Ca2+ leak; CaMKII
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39420
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