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Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development

Gerl, Katharina, Steppan, Dominik, Fuchs, Michaela, Wagner, Charlotte, Willam, Carsten, Kurtz, Armin and Kurt, Birgül (2017) Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development. The American Journal of Pathology 187 (7), pp. 1496-1511.

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Other URL: http://doi.org/10.1016/j.ajpath.2017.03.014


Abstract

Intrauterine hypoxia is a reason for impaired kidney development. The cellular and molecular pathways along which hypoxia exerts effects on nephrogenesis are not well understood. They are likely triggered by hypoxia-inducible transcription factors (HIFs), and their effects appear to be dependent on the cell compartment contributing to kidney formation. In this study, we investigated the effects ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie
Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Armin Kurtz
Identification Number:
ValueType
10.1016/j.ajpath.2017.03.014DOI
Keywords:LINDAU TUMOR-SUPPRESSOR; GSDM FAMILY GENES; BRANCHING MORPHOGENESIS; MAMMALIAN KIDNEY; EXPERIMENTAL GLOMERULONEPHRITIS; INDUCIBLE FACTOR-1-ALPHA; NEPHRON DIFFERENTIATION; RENAL ERYTHROPOIETIN; GROWTH-FACTOR; MOUSE KIDNEY;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39421
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