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Activation of Hypoxia Signaling in Stromal Progenitors Impairs Kidney Development

Gerl, Katharina ; Steppan, Dominik ; Fuchs, Michaela ; Wagner, Charlotte ; Willam, Carsten ; Kurtz, Armin ; Kurt, Birgül



Abstract

Intrauterine hypoxia is a reason for impaired kidney development. The cellular and molecular pathways along which hypoxia exerts effects on nephrogenesis are not well understood. They are likely triggered by hypoxia-inducible transcription factors (HIFs), and their effects appear to be dependent on the cell compartment contributing to kidney formation. In this study, we investigated the effects ...

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