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SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina

Kugler, Martina, Schlecht, Anja, Fuchshofer, Rudolf, Schmitt, Sabrina I., Kleiter, Ingo, Aigner, Ludwig, Tamm, Ernst R. and Braunger, Barbara M. (2017) SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina. Histochemistry and Cell Biology 148 (1), pp. 21-32.

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Other URL: http://doi.org/10.1007/s00418-017-1549-5


Abstract

The transforming growth factor-beta (TGF-beta) pathway contributes to maintain the quiescence of adult neural stem and progenitor cells in the brain. In the retina, Muller cells are discussed to represent a glial cell population with progenitor-like characteristics. Here, we aimed to investigate if elevated TGF-beta signaling modulates the proliferation of Muller cells during retinal development. ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identification Number:
ValueType
10.1007/s00418-017-1549-5DOI
Keywords:GROWTH-FACTOR-BETA; OPTIC-NERVE HEAD; STEM-CELLS; NEURAL REGENERATION; NEUROTOXIC INJURY; WNT/BETA-CATENIN; MARKER NESTIN; IN-VIVO; MOUSE; ACTIVATION; SMAD7; TGF-beta signaling; Muller cells; Progenitor cells; Retina
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39428
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