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SMAD7 deficiency stimulates Müller progenitor cell proliferation during the development of the mammalian retina

Kugler, Martina ; Schlecht, Anja ; Fuchshofer, Rudolf ; Schmitt, Sabrina I. ; Kleiter, Ingo ; Aigner, Ludwig ; Tamm, Ernst R. ; Braunger, Barbara M.



Abstract

The transforming growth factor-beta (TGF-beta) pathway contributes to maintain the quiescence of adult neural stem and progenitor cells in the brain. In the retina, Muller cells are discussed to represent a glial cell population with progenitor-like characteristics. Here, we aimed to investigate if elevated TGF-beta signaling modulates the proliferation of Muller cells during retinal development. ...

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