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Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress

Ingoglia, Giada, Sag, Can Martin, Rex, Nikolai, De Franceschi, Lucia, Vinchi, Francesca, Cimino, James, Petrillo, Sara , Wagner, Stefan, Kreitmeier, Klaus, Silengo, Lorenzo, Altruda, Fiorella, Maier, Lars S., Hirsch, Emilio , Ghigo, Alessandra and Tolosano, Emanuela (2017) Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress. Free Radical Biology and Medicine 108, pp. 452-464.

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Other URL: http://doi.org/10.1016/j.freeradbiomed.2017.04.003


Abstract

Heart failure is a leading cause of morbidity and mortality in patients affected by different disorders associated to intravascular hemolysis. The leading factor is the presence of pathologic amount of pro-oxidant free heme in the bloodstream, due to the exhaustion of the natural heme scavenger Hemopexin (Hx). Here, we evaluated whether free heme directly affects cardiac function, and tested the ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1016/j.freeradbiomed.2017.04.003DOI
Keywords:SICKLE-CELL-DISEASE; TRANSFUSION-DEPENDENT THALASSEMIA; ISCHEMIA-REPERFUSION INJURY; MITRAL-VALVE REPAIR; HEART-FAILURE; ERYTHROID-DIFFERENTIATION; ENDOTHELIAL-CELLS; CARDIAC MYOCYTES; BETA-THALASSEMIA; PROTECTIVE ROLE; Heme; Hemopexin; ROS; Heart; Systolic function
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39436
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