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Hemopexin counteracts systolic dysfunction induced by heme-driven oxidative stress

Ingoglia, Giada ; Sag, Can Martin ; Rex, Nikolai ; De Franceschi, Lucia ; Vinchi, Francesca ; Cimino, James ; Petrillo, Sara ; Wagner, Stefan ; Kreitmeier, Klaus ; Silengo, Lorenzo ; Altruda, Fiorella ; Maier, Lars S. ; Hirsch, Emilio ; Ghigo, Alessandra ; Tolosano, Emanuela



Abstract

Heart failure is a leading cause of morbidity and mortality in patients affected by different disorders associated to intravascular hemolysis. The leading factor is the presence of pathologic amount of pro-oxidant free heme in the bloodstream, due to the exhaustion of the natural heme scavenger Hemopexin (Hx). Here, we evaluated whether free heme directly affects cardiac function, and tested the ...

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