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Topically applied virus-like particles containing HIV-1 Pr55gag protein reach skin antigen-presenting cells after mild skin barrier disruption

Rancan, Fiorenza, Afraz, Zahra, Hadam, Sabrina, Weiß, Lina, Perrin, Hélène, Kliche, Alexander, Schrade, Petra, Bachmann, Sebastian, Schäfer-Korting, Monika, Blume-Peytavi, Ulrike, Wagner, Ralf, Combadière, Béhazine and Vogt, Annika (2017) Topically applied virus-like particles containing HIV-1 Pr55gag protein reach skin antigen-presenting cells after mild skin barrier disruption. Journal of Controlled Release 268, pp. 296-304.

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Other URL: http://doi.org/10.1016/j.jconrel.2017.10.033


Abstract

Loading of antigen on particles as well as the choice of skin as target organ for vaccination were independently described as effective dose-sparing strategies for vaccination. Combining these two strategies, sufficient antigen recognition may be achievable via the transcutaneous route even with minimal-invasive tools. Here, we investigated the skin penetration and cellular uptake of topically ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene
Identification Number:
ValueType
10.1016/j.jconrel.2017.10.033DOI
Keywords:DERMAL DENDRITIC CELLS; IMMUNE-RESPONSES; LANGERHANS CELLS; NEEDLE-FREE; T-CELLS; VACCINATION; IMMUNIZATION; EXPRESSION; ADJUVANT; DELIVERY; Skin penetration; Hair follicle; Antigen delivery; Transcutaneous vaccination; Nanoparticles
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39453
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