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The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

Peters, Sebastian ; Zitzelsperger, Eva ; Kuespert, Sabrina ; Iberl, Sabine ; Heydn, Rosmarie ; Johannesen, Siw ; Petri, Susanne ; Aigner, Ludwig ; Thal, Dietmar R. ; Hermann, Andreas ; Weishaupt, Jochen H. ; Bruun, Tim-Henrik ; Bogdahn, Ulrich



Abstract

Amyotrophic lateral sclerosis (ALS) represents a fatal orphan disease with high unmet medical need, and a life time risk of approx. 1/400 persons per population. Based on increasing knowledge on pathophysiology including genetic and molecular changes, epigenetics, and immune dysfunction, inflammatory as well as fibrotic processes may contribute to the heterogeneity and dynamics of ALS. Animal and ...

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