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The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis

Peters, Sebastian, Zitzelsperger, Eva, Kuespert, Sabrina, Iberl, Sabine, Heydn, Rosmarie, Johannesen, Siw, Petri, Susanne, Aigner, Ludwig, Thal, Dietmar R. , Hermann, Andreas, Weishaupt, Jochen H., Bruun, Tim-Henrik and Bogdahn, Ulrich (2017) The TGF-β System As a Potential Pathogenic Player in Disease Modulation of Amyotrophic Lateral Sclerosis. Frontiers in Neurology 8.

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Other URL: http://doi.org/10.3389/fneur.2017.00669

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Amyotrophic lateral sclerosis (ALS) represents a fatal orphan disease with high unmet medical need, and a life time risk of approx. 1/400 persons per population. Based on increasing knowledge on pathophysiology including genetic and molecular changes, epigenetics, and immune dysfunction, inflammatory as well as fibrotic processes may contribute to the heterogeneity and dynamics of ALS. Animal and ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Neurologie
Identification Number:
ValueType
10.3389/fneur.2017.00669DOI
Keywords:HEMATOPOIETIC STEM-CELLS; REGULATORY T-CELLS; GROWTH-FACTOR-BETA; ADULT HIPPOCAMPAL NEUROGENESIS; CENTRAL-NERVOUS-SYSTEM; SPINAL-CORD; NEUROPROTECTIVE FUNCTIONS; SUBSTANTIA-NIGRA; BRAIN; TGF-BETA-1; amyotrophic lateral sclerosis; TGF-beta; immunity; adult neurogenic niche; fibrosis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39463
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