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Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis

Grund, Thomas, Goyon, Stephanie, Li, Yuting, Eliava, Marina, Liu, Haikun, Charlet, Alexandre, Grinevich, Valery and Neumann, Inga D. (2017) Neuropeptide S Activates Paraventricular Oxytocin Neurons to Induce Anxiolysis. The Journal of Neuroscience 37 (50), pp. 12214-12225.

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Other URL: http://doi.org/10.1523/JNEUROSCI.2161-17.2017


Abstract

Neuropeptides, such as neuropeptide S (NPS) and oxytocin (OXT), represent potential options for the treatment of anxiety disorders due to their potent anxiolytic profile. In this study, we aimed to reveal the mechanisms underlying the behavioral action of NPS, and present a chain of evidence that the effects of NPS within the hypothalamic paraventricular nucleus (PVN) are mediated via actions on ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Identification Number:
ValueType
10.1523/JNEUROSCI.2161-17.2017DOI
Keywords:CORTICOTROPIN-RELEASING-FACTOR; BRAIN OXYTOCIN; FOOD-INTAKE; EFFERENT PROJECTIONS; VASOPRESSIN RELEASE; EXPRESSING NEURONS; SOCIAL BEHAVIORS; CENTRAL AMYGDALA; LOCUS-COERULEUS; LACTATING RATS; anxiety; DREADD; GCaMP6s; microdialysis; neuropeptide S; oxytocin
Dewey Decimal Classification:500 Science > 590 Zoological sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39465
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