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Longitudinal Diffusion Tensor Imaging-Based Assessment of Tract Alterations: An Application to Amyotrophic Lateral Sclerosis

Baldaranov, Dobri ; Khomenko, Andrei ; Kobor, Ines ; Bogdahn, Ulrich ; Gorges, Martin ; Kassubek, Jan ; Müller, Hans-Peter


Objective: The potential of magnetic resonance imaging (MRI) as a technical biomarker for cerebral microstructural alterations in neurodegenerative diseases is under investigation. In this study, a framework for the longitudinal analysis of diffusion tensor imaging (DTI)-based mapping was applied to the assessment of predefined white matter tracts in amyotrophic lateral sclerosis (ALS), as an ...


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