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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Muttenthaler, Markus ; Andersson, Åsa ; Vetter, Irina ; Menon, Rohit ; Busnelli, Marta ; Ragnarsson, Lotten ; Bergmayr, Christian ; Arrowsmith, Sarah ; Deuis, Jennifer R. ; Chiu, Han Sheng ; Palpant, Nathan J. ; O’Brien, Margaret ; Smith, Terry J. ; Wray, Susan ; Neumann, Inga D. ; Gruber, Christian W. ; Lewis, Richard J. ; Alewood, Paul F.



Abstract

Oxytocin and vasopressin mediate various physiological functions that are important for osmoregulation, reproduction, cardiovascular function, social behavior, memory, and learning through four G protein-coupled receptors that are also implicated in high-profile disorders. Targeting these receptors is challenging because of the difficulty in obtaining ligands that retain selectivity across ...

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