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Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species

Muttenthaler, Markus, Andersson, Åsa, Vetter, Irina , Menon, Rohit, Busnelli, Marta , Ragnarsson, Lotten , Bergmayr, Christian, Arrowsmith, Sarah , Deuis, Jennifer R., Chiu, Han Sheng, Palpant, Nathan J., O’Brien, Margaret, Smith, Terry J., Wray, Susan, Neumann, Inga D., Gruber, Christian W. , Lewis, Richard J. and Alewood, Paul F. (2017) Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling 10 (508), eaan3398.

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Other URL: http://doi.org/10.1126/scisignal.aan3398


Abstract

Oxytocin and vasopressin mediate various physiological functions that are important for osmoregulation, reproduction, cardiovascular function, social behavior, memory, and learning through four G protein-coupled receptors that are also implicated in high-profile disorders. Targeting these receptors is challenging because of the difficulty in obtaining ligands that retain selectivity across ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann)
Identification Number:
ValueType
10.1126/scisignal.aan3398DOI
Keywords:PHASE PEPTIDE-SYNTHESIS; SOCIAL BEHAVIORS; HUMAN MYOMETRIUM; CARDIOVASCULAR-SYSTEM; VASOPRESSIN RECEPTORS; ARGININE-VASOPRESSIN; HUMAN CARDIOMYOCYTES; ANTAGONIST ATOSIBAN; NONPEPTIDE AGONISTS; INTRANASAL OXYTOCIN;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39477
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