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Antitubercular and Cytotoxic Chlorinated seco-Cyclohexenes from Uvaria alba

Macabeo, Allan Patrick G. ; Letada, Arianne G. ; Budde, Simon ; Faderl, Christian ; Dahse, Hans-Martin ; Franzblau, Scott G. ; Alejandro, Grecebio Jonathan D. ; Pierens, Gregory K. ; Garson, Mary J.


Two new chlorine-containing polyoxygenated seco-cyclohexenes, albanols A (1) and B (2), along with the oxepinone metabolite grandiuvarone (3) were isolated from the endemic Philippine Annonaceae plant Uvaria alba. Both new compounds exhibited modest antitubercular activity. Compound 1 showed cytostatic activity (ranging from 1-50 mu M) against HeLa cells and weak antiproliferative activity against HUVEC and K-562 cells with GI50 values of 106 and 81 mu M, respectively.

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