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Toehold-enhanced LNA probes for selective pull down and single-molecule analysis of native chromatin

Hermans, Nicolaas ; Huisman, Juriën Jori ; Brouwer, Thomas Bauke ; Schächner, Christopher ; van Heusden, G. Paul H. ; Griesenbeck, Joachim ; van Noort, John



Abstract

The organization of DNA into chromatin is thought to regulate gene expression in eukaryotes. To study its structure in vitro, there is a need for techniques that can isolate specific chromosomal loci of natively assembled chromatin. Current purification methods often involve chemical cross-linking to preserve the chromatin composition. However, such cross-linking may affect the native structure. ...

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