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Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy

Machado, Yoan , Duinkerken, Sanne, Hoepflinger, Veronika, Mayr, Melissa, Korotchenko, Evgeniia, Kurtaj, Almedina, Pablos, Isabel, Steiner, Markus , Stoecklinger, Angelika, Lübbers, Joyce, Schmid, Maximillian, Ritter, Uwe, Scheiblhofer, Sandra, Ablinger, Michael, Wally, Verena, Hochmann, Sarah, Raninger, Anna M., Strunk, Dirk , van Kooyk, Yvette, Thalhamer, Josef and Weiss, Richard (2017) Synergistic effects of dendritic cell targeting and laser-microporation on enhancing epicutaneous skin vaccination efficacy. Journal of Controlled Release 266, pp. 87-99.

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Other URL: http://doi.org/10.1016/j.jconrel.2017.09.020


Abstract

Due to its unique immunological properties, the skin is an attractive target tissue for allergen-specific immunotherapy. In our current work, we combined a dendritic cell targeting approach with epicutaneous immunization using an ablative fractional laser to generate defined micropores in the upper layers of the skin. By coupling the major birch pollen allergen Bet v 1 to mannan from S. ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Immunologie
Identification Number:
ValueType
10.1016/j.jconrel.2017.09.020DOI
Keywords:REGULATORY T-CELLS; C-TYPE LECTINS; LANGERHANS CELLS; ALLERGEN IMMUNOTHERAPY; BIRCH POLLEN; TRANSCUTANEOUS IMMUNOTHERAPY; GENERATED MICROPORES; COMPLEMENT-RECEPTORS; ATOPIC-DERMATITIS; IMMUNE-RESPONSES; Dendritic cell targeting; C type lectin receptors; Mannan; Skin vaccination; Laser microporation; Epicutaneous immunization; Hypoallergen; Specific immunotherapy
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39554
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