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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Liang, Hua ; Deng, Liufu ; Hou, Yuzhu ; Meng, Xiangjiao ; Huang, Xiaona ; Rao, Enyu ; Zheng, Wenxin ; Mauceri, Helena ; Mack, Matthias ; Xu, Meng ; Fu, Yang-Xin ; Weichselbaum, Ralph R.


Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING. The STING/type I interferon pathway enhances ...


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