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Host STING-dependent MDSC mobilization drives extrinsic radiation resistance

Liang, Hua, Deng, Liufu, Hou, Yuzhu, Meng, Xiangjiao, Huang, Xiaona, Rao, Enyu, Zheng, Wenxin, Mauceri, Helena, Mack, Matthias, Xu, Meng, Fu, Yang-Xin and Weichselbaum, Ralph R. (2017) Host STING-dependent MDSC mobilization drives extrinsic radiation resistance. Nature Communications 8 (1).

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Other URL: http://doi.org/10.1038/s41467-017-01566-5

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Radiotherapy induces and promotes innate and adaptive immunity in which host STING plays an important role. However, radioresistance in irradiated tumors can also develop, resulting in relapse. Here we report a mechanism by which extrinsic resistance develops after local ablative radiation that relies on the immunosuppressive action of STING. The STING/type I interferon pathway enhances ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin I
Identification Number:
ValueType
10.1038/s41467-017-01566-5DOI
Keywords:PERSISTENT LCMV INFECTION; IMMUNOGENIC TUMORS; CELLS; CANCER; CCR2; INFLAMMATION; BLOCKADE; AUTOIMMUNITY; RADIOTHERAPY; RECOGNITION;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39557
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