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Riluzole: a potential therapeutic intervention in human brain tumor stem-like cells

Sperling, Swetlana ; Aung, Thiha ; Martin, Sabine ; Rohde, Veit ; Ninkovic, Milena



Abstract

A small subpopulation of tumor stem-like cells has the capacity to initiate tumors and mediate radio- and chemoresistance in diverse cancers hence also in glioblastoma (GBM). It has been reported that this capacity of tumor initiation in the brain is mainly dependent on the body's nutrient supply. This population of so-called brain tumor initiating or brain tumor stem-like cells (BTSCs) is able ...

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