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Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4

Perera, Ruwan K., Fischer, Thomas H., Wagner, Michael , Dewenter, Matthias, Vettel, Christiane, Bork, Nadja I., Maier, Lars S., Conti, Marco, Wess, Juergen, El-Armouche, Ali , Hasenfuß, Gerd and Nikolaev, Viacheslav O. (2017) Atropine augments cardiac contractility by inhibiting cAMP-specific phosphodiesterase type 4. Scientific Reports 7 (1).

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Other URL: http://doi.org/10.1038/s41598-017-15632-x

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Abstract

Atropine is a clinically relevant anticholinergic drug, which blocks inhibitory effects of the parasympathetic neurotransmitter acetylcholine on heart rate leading to tachycardia. However, many cardiac effects of atropine cannot be adequately explained solely by its antagonism at muscarinic receptors. In isolated mouse ventricular cardiomyocytes expressing a Forster resonance energy transfer ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1038/s41598-017-15632-xDOI
Keywords:HUMAN ATRIAL MYOCARDIUM; MUSCARINIC RECEPTORS; KNOCKOUT MICE; INTACT-CELLS; HEART; ACETYLCHOLINE; PATHOPHYSIOLOGY; ARRHYTHMIAS; RESPONSES; SYSTEM;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39579
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