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Efficacy of Prolonged- and Immediate-release Tacrolimus in Kidney Transplantation: A Pooled Analysis of Two Large, Randomized, Controlled Trials

Krämer, B.K. ; Albano, L. ; Banas, B. ; Charpentier, B. ; Bäckman, L. ; Tedesco-Silva, H. ; Lehner, F. ; Mondragón-Ramírez, G.A. ; Glyda, M. ; Cassuto-Viguier, E. ; Viklický, O. ; Mourad, G. ; Rigotti, P. ; Schleibner, S. ; Kamar, N.



Abstract

Background. Two large, prospective studies (12-03; OSAKA) compared the efficacy and tolerability of prolonged-release versus immediate-release tacrolimus in kidney transplant patients also receiving mycophenolate mofetil and low-dose corticosteroids (without induction therapy). Methods. Data were combined into one database to compare results over 24 weeks using 3 alternative endpoints: ...

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