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Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model

Pfeifer, Christian G., Fisher, Matthew B., Saxena, Vishal, Kim, Minwook, Henning, Elizabeth A., Steinberg, David A., Dodge, George R. and Mauck, Robert L. (2017) Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model. Tissue Engineering Part C: Methods 23 (11), pp. 745-753.

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Other URL: http://doi.org/10.1089/ten.tec.2017.0109


Abstract

After cartilage injury and repair, the subchondral bone plate remodels. Skeletal maturity likely impacts both bone remodeling and inherent cartilage repair capacity. The objective of this study was to evaluate subchondral bone remodeling as a function of injury type, repair scenario, and skeletal maturity in a Yucatan minipig model. Cartilage defects (4 mm) were created bilaterally in the ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Unfallchirurgie
Identification Number:
ValueType
10.1089/ten.tec.2017.0109DOI
Keywords:AUTOLOGOUS CHONDROCYTE IMPLANTATION; FULL-THICKNESS DEFECTS; GROWTH-FACTOR DELIVERY; ARTICULAR-CARTILAGE; CHONDRAL DEFECTS; OSTEOCHONDRAL REPAIR; MARROW STIMULATION; FEMORAL CONDYLE; CANINE MODEL; KNEE; subchondral bone; cartilage; microfracture; skeletal maturity
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39622
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