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Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization

Schlecht, Anja ; Leimbeck, Sarah V. ; Jägle, Herbert ; Feuchtinger, Annette ; Tamm, Ernst R. ; Braunger, Barbara M.



Abstract

The molecular pathogenesis of choroidal neovascularization (CNV), an angiogenic process that critically contributes to vision loss in age-related macular degeneration, is unclear. Herein, we analyzed the role of transforming growth factor (TGF)-beta signaling for CNV formation by generating a series of mutant mouse models with induced conditional deletion of TGF-beta signaling in the entire eye, ...

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