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Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization

Schlecht, Anja, Leimbeck, Sarah V., Jägle, Herbert, Feuchtinger, Annette, Tamm, Ernst R. and Braunger, Barbara M. (2017) Deletion of Endothelial Transforming Growth Factor–β Signaling Leads to Choroidal Neovascularization. The American Journal of Pathology 187 (11), pp. 2570-2589.

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Other URL: http://doi.org/10.1016/j.ajpath.2017.06.018


Abstract

The molecular pathogenesis of choroidal neovascularization (CNV), an angiogenic process that critically contributes to vision loss in age-related macular degeneration, is unclear. Herein, we analyzed the role of transforming growth factor (TGF)-beta signaling for CNV formation by generating a series of mutant mouse models with induced conditional deletion of TGF-beta signaling in the entire eye, ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Augenheilkunde
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie > Prof. Dr. Ernst Tamm
Identification Number:
ValueType
10.1016/j.ajpath.2017.06.018DOI
Keywords:RETINAL-PIGMENT EPITHELIUM; ACTIVATED PROTEIN-KINASE; BASAL LAMINAR DEPOSIT; MACULAR DEGENERATION; TGF-BETA; IMMUNOHISTOCHEMICAL LOCALIZATION; FENESTRATED ENDOTHELIA; TGF-BETA-1 EXPRESSION; DIABETIC-RETINOPATHY; ELECTRON-MICROSCOPY;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39623
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