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Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility

Huang, Guozheng , Drakopoulos, Antonios , Saedtler, Marco, Zou, Huijuan, Meinel, Lorenz , Heilmann, Jörg and Decker, Michael (2017) Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility. Bioorganic & Medicinal Chemistry Letters 27 (21), pp. 4937-4941.

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Other URL: http://doi.org/10.1016/j.bmcl.2017.08.045


Abstract

The alkaloid rutaecarpine and its derivatives have been described as cytotoxic and hold potential as antitumor agents. Nevertheless, their synthesis is demanding and compounds display poor water solubility. Herein, we describe the synthesis of two sets of rutaecarpine derivatives with amine functions to improve solubility. Using a classic shake-flask experiment and a potentiometric titration ...

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Item type:Article
Date:2017
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Biology (Prof. Heilmann)
Identification Number:
ValueType
10.1016/j.bmcl.2017.08.045DOI
Keywords:MICROEMULSION SYSTEM; NATURAL-PRODUCTS; IN-VIVO; EVODIAMINE; ANALOGS; RATS; EXTRACTS; DELIVERY; AGENTS; SERUM; Rutaecarpine; SiriusT3; Cytotoxicity; Solubility
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39626
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