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Cytotoxic properties of the alkaloid rutaecarpine and its oligocyclic derivatives and chemical modifications to enhance water-solubility

Huang, Guozheng ; Drakopoulos, Antonios ; Saedtler, Marco ; Zou, Huijuan ; Meinel, Lorenz ; Heilmann, Jörg ; Decker, Michael


The alkaloid rutaecarpine and its derivatives have been described as cytotoxic and hold potential as antitumor agents. Nevertheless, their synthesis is demanding and compounds display poor water solubility. Herein, we describe the synthesis of two sets of rutaecarpine derivatives with amine functions to improve solubility. Using a classic shake-flask experiment and a potentiometric titration ...


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