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Increased cFLIP expression in thymic epithelial tumors blocks autophagy via NF-κB signalling

Belharazem, Djeda ; Grass, Albert ; Paul, Cornelia ; Vitacolonna, Mario ; Schalke, Berthold ; Rieker, Ralf J. ; Körner, Daniel ; Jungebluth, Philipp ; Simon-Keller, Katja ; Hohenberger, Peter ; Roessner, Eric M. ; Wiebe, Karsten ; Gräter, Thomas ; Kyriss, Thomas ; Ott, German ; Geserick, Peter ; Leverkus, Martin ; Ströbel, Philipp ; Marx, Alexander



Abstract

The anti-apoptotic cellular FLICE-like inhibitory protein cFLIP plays a pivotal role in normal tissues homoeostasis and the development of many tumors, but its role in normal thymus (NT), thymomas and thymic carcinomas (TC) is largely unknown. Expression, regulation and function of cFLIP were analyzed in biopsies of NT, thymomas, thymic squamous cell carcinomas (TSCC), thymic epithelial cells ...

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