We present results for the ratios of mean (MB), variance (sigma(2)(B)), skewness (SB) and kurtosis(kappa B) of net baryon-number fluctuations obtained in lattice QCD calculations with physical values of light and strange quark masses. Using next-to-leading order Taylor expansions in baryon chemical potential we find that qualitative features of these ratios closely resemble the corresponding experimentally measured cumulant ratios of net proton-number fluctuations for beam energies down to root s(NN) >= 19.6 GeV. We show that the difference in cumulant ratios for the mean net baryon-number, M-B/sigma(2)(B) = chi(1)(B) (T, mu(B)) / chi(2)(B) (T, mu(B)), and the normalized skewness, S-B sigma(B) = chi(B)(3) (T, mu(B)) / chi(B)(2) (T, mu B), naturally arises in QCD thermodynamics. Moreover, we establish a close relation between skewness and kurtosis ratios, S-B sigma(3)(B) / M-B = chi(B)(3) (T, mu(B)) / chi(B)(1) (T, mu(B)) and kappa(B)sigma(2)(B) = chi(B)(4) (T, mu(B)) /chi(B)(2) (T, mu(B)), valid at small values of the baryon chemical potential.