Leopold, Stephanie A., Zeilbeck, Ludwig F., Weber, Gregor, Seitz, Roswitha, Bösl, Michael R., Jägle, Herbert, Fuchshofer, Rudolf, Tamm, Ernst R. and Ohlmann, Andreas (2017) Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma. Scientific Reports 7 (1).
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Other URL: http://doi.org/10.1038/s41598-017-14423-8
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Abstract
Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protects retinal neurons from experimental acute injury, we were interested to learn if Norrin attenuates chronic damage of retinal ganglion cells (RGC) and their axons in a mouse model of glaucoma. Transgenic mice overexpressing Norrin in the retina (Pax6-Norrin) were generated and crossed with DBA/2J ...
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| Item type: | Article | ||||
|---|---|---|---|---|---|
| Date: | 2017 | ||||
| Institutions: | Biology, Preclinical Medicine > Institut für Anatomie Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie | ||||
| Identification Number: |
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| Keywords: | RETINAL GANGLION-CELLS; GROWTH-FACTOR-I; WNT/BETA-CATENIN; DBA/2J MOUSE; VASCULAR DEVELOPMENT; TRABECULAR MESHWORK; PIGMENTARY GLAUCOMA; SIGNALING PATHWAY; NEURONAL SURVIVAL; MUTANT MICE; | ||||
| Dewey Decimal Classification: | 500 Science > 570 Life sciences | ||||
| Status: | Published | ||||
| Refereed: | Yes, this version has been refereed | ||||
| Created at the University of Regensburg: | Yes | ||||
| Item ID: | 39654 |
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