Go to content
UR Home

Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma

Leopold, Stephanie A., Zeilbeck, Ludwig F., Weber, Gregor, Seitz, Roswitha, Bösl, Michael R., Jägle, Herbert, Fuchshofer, Rudolf, Tamm, Ernst R. and Ohlmann, Andreas (2017) Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma. Scientific Reports 7 (1).

Full text not available from this repository.

at publisher (via DOI)

Other URL: http://doi.org/10.1038/s41598-017-14423-8

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protects retinal neurons from experimental acute injury, we were interested to learn if Norrin attenuates chronic damage of retinal ganglion cells (RGC) and their axons in a mouse model of glaucoma. Transgenic mice overexpressing Norrin in the retina (Pax6-Norrin) were generated and crossed with DBA/2J ...

plus


Export bibliographical data



Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Anatomie
Biology, Preclinical Medicine > Institut für Anatomie > Lehrstuhl für Humananatomie und Embryologie
Identification Number:
ValueType
10.1038/s41598-017-14423-8DOI
Keywords:RETINAL GANGLION-CELLS; GROWTH-FACTOR-I; WNT/BETA-CATENIN; DBA/2J MOUSE; VASCULAR DEVELOPMENT; TRABECULAR MESHWORK; PIGMENTARY GLAUCOMA; SIGNALING PATHWAY; NEURONAL SURVIVAL; MUTANT MICE;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39654
Owner only: item control page
  1. Homepage UR

University Library

Publication Server

Contact:

Publishing: oa@ur.de

Dissertations: dissertationen@ur.de

Research data: daten@ur.de

Contact persons