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Norrin protects optic nerve axons from degeneration in a mouse model of glaucoma

Leopold, Stephanie A. ; Zeilbeck, Ludwig F. ; Weber, Gregor ; Seitz, Roswitha ; Bösl, Michael R. ; Jägle, Herbert ; Fuchshofer, Rudolf ; Tamm, Ernst R. ; Ohlmann, Andreas



Abstract

Norrin is a secreted signaling molecule activating the Wnt/beta-catenin pathway. Since Norrin protects retinal neurons from experimental acute injury, we were interested to learn if Norrin attenuates chronic damage of retinal ganglion cells (RGC) and their axons in a mouse model of glaucoma. Transgenic mice overexpressing Norrin in the retina (Pax6-Norrin) were generated and crossed with DBA/2J ...

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