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Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration

Lindborg, Jane A., Mack, Matthias and Zigmond, Richard E. (2017) Neutrophils Are Critical for Myelin Removal in a Peripheral Nerve Injury Model of Wallerian Degeneration. The Journal of Neuroscience 37 (43), pp. 10258-10277.

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Other URL: http://doi.org/10.1523/JNEUROSCI.2085-17.2017


Abstract

Wallerian degeneration (WD) is considered an essential preparatory stage to the process of axonal regeneration. In the peripheral nervous system, infiltrating monocyte-derived macrophages, which use the chemokine receptor CCR2 to gain entry to injured tissues from the bloodstream, are purportedly necessary for efficient WD. However, our laboratory has previously reported that myelin clearance in ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin II
Identification Number:
ValueType
10.1523/JNEUROSCI.2085-17.2017DOI
Keywords:MONOCYTE CHEMOATTRACTANT PROTEIN-1; MACROPHAGE RECRUITMENT; APOPTOTIC NEUTROPHILS; CHEMOKINE RECEPTOR; SCHWANN-CELLS; AXONAL DEGENERATION; FUNCTIONAL RECOVERY; GRANULE DEFICIENCY; NEUROPATHIC PAIN; BLOOD MONOCYTES; axotomy; macrophages; neutrophils; phagocytosis; sciatic nerve; Wallerian degeneration
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39657
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