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Electron transfer pathways in a light, oxygen, voltage (LOV) protein devoid of the photoactive cysteine

Kopka, Benita ; Magerl, Kathrin ; Savitsky, Anton ; Davari, Mehdi D. ; Röllen, Katrin ; Bocola, Marco ; Dick, Bernhard ; Schwaneberg, Ulrich ; Jaeger, Karl-Erich ; Krauss, Ulrich


Blue-light absorption by the flavin chromophore in light, oxygen, voltage (LOV) photoreceptors triggers photochemical reactions that lead to the formation of a flavin-cysteine adduct. While it has long been assumed that adduct formation is essential for signaling, it was recently shown that LOV photoreceptor variants devoid of the photoactive cysteine can elicit a functional response and that ...


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