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Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia

Krishnasamy, Kashyap, Limbourg, Anne, Kapanadze, Tamar, Gamrekelashvili, Jaba, Beger, Christian, Häger, Christine, Lozanovski, Vladimir J., Falk, Christine S., Napp, L. Christian, Bauersachs, Johann, Mack, Matthias, Haller, Hermann, Weber, Christian, Adams, Ralf H. and Limbourg, Florian P. (2017) Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia. Nature Communications 8 (1).

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Other URL: http://doi.org/10.1038/s41467-017-00953-2

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Ischemia causes an inflammatory response that is intended to restore perfusion and homeostasis yet often aggravates damage. Here we show, using conditional genetic deletion strategies together with adoptive cell transfer experiments in a mouse model of hind limb ischemia, that blood vessels control macrophage differentiation and maturation from recruited monocytes via Notch signaling, which in ...

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Item type:Article
Date:2017
Institutions:Medicine > Abteilung für Nephrologie
Identification Number:
ValueType
10.1038/s41467-017-00953-2DOI
Keywords:ENDOTHELIAL-CELLS; POSTNATAL ARTERIOGENESIS; GENE-EXPRESSION; DENDRITIC CELLS; RBP-J; NOTCH; POLARIZATION; ACTIVATION; MONOCYTES; ANGIOGENESIS;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39669
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