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HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category

Holzschuh, Maria-Anna, Czyz, Zbigniew, Hauke, Sven, Inwald, Elisabeth C, Polzer, Bernhard and Brockhoff, Gero (2017) HER2 FISH results in breast cancers with increased CEN17 signals using alternative chromosome 17 probes - reclassifying cases in the equivocal category. Histopathology 71 (4), pp. 610-625.

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Other URL: http://doi.org/10.1111/his.13253


Abstract

Aims: HER2 testing of invasive breast cancer by in-situ hybridization guides therapy decisions. Probing HER2 and centromere of chromosome 17 (cen17) simultaneously is supposed to reveal both a potential HER2 gene amplification and polysomy 17. However, a considerable number of breast cancer patients with quasi polysomy 17 are considered 'equivocal', which is diagnostically meaningless. Moreover, ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde)
Identification Number:
ValueType
10.1111/his.13253DOI
Keywords:; breast cancer; cen17; FISH; Her2; polysomy
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39694
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