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Asthmatic farm children show increased CD3 + CD8 low T-cells compared to non-asthmatic farm children

Twardziok, Monika ; Schröder, Paul C. ; Krusche, Johanna ; Casaca, Vera I. ; Illi, Sabina ; Böck, Andreas ; Loss, Georg J. ; Kabesch, Michael ; Toncheva, Antoaneta A. ; Roduit, Caroline ; Depner, Martin ; Genuneit, Jon ; Renz, Harald ; Roponen, Marjut ; Weber, Juliane ; Braun-Fahrländer, Charlotte ; Riedler, Josef ; Lauener, Roger ; Vuitton, Dominique Angèle ; Dalphin, Jean-Charles ; Pekkanen, Juha ; von Mutius, Erika ; Schaub, Bianca ; Hyvärinen, Anne ; Karvonen, Anne M. ; Kirjavainen, Pirkka V. ; Remes, Sami ; Kaulek, Vincent ; Dalphin, Marie-Laure ; Ege, Markus ; Pfefferle, Petra I. ; Doekes, Gert



Abstract

Several studies report an important role of CD8(+) cytotoxic T-cells in atopy. Farm children show protection against atopy development, partly explained by CD4(+) T-cell subtypes. Additional effects of CD8(+) T-cells are unknown being investigated in this study within the PASTURE/EFRAIM birth cohort in PBMCs from farming and non-farming 6-year-old (N = 76) German children. CD3(+) CD8(+) CD25(+) ...

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