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6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms

Fuchs, Oliver , Gorlanova, Olga, Latzin, Philipp , Schmidt, Anne, Schieck, Maximilian, Toncheva, Antoaneta A. , Michel, Sven, Gaertner, Vincent D. , Kabesch, Michael and Frey, Urs (2017) 6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms. Journal of Allergy and Clinical Immunology 140 (4), pp. 1015-1023.

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Other URL: http://doi.org/10.1016/j.jaci.2016.11.048


Abstract

Background: Exhaled nitric oxide (eNO) is a biomarker of airway inflammation and seems to precede respiratory symptoms, such as asthma, in childhood. Identifying genetic determinants of postnatal eNO levels might aid in unraveling the role of eNO in epithelial function or airway inflammation and disease. Objective: We sought to identify genetic determinants of early postnatal eNO levels and ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Kinder- und Jugendmedizin
Identification Number:
ValueType
10.1016/j.jaci.2016.11.048DOI
Keywords:LUNG DEVELOPMENT; EPITHELIAL-CELLS; HEALTHY INFANTS; GROWTH-FACTOR; ASTHMA; GENOME; CHILDREN; DISEASE; CTCF; CHILDHOOD; Infants; exhaled nitric oxide; genetics; airway inflammation; genome-wide association study; wheeze; asthma
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39719
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