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6q12 and 11p14 variants are associated with postnatal exhaled nitric oxide levels and respiratory symptoms

Fuchs, Oliver ; Gorlanova, Olga ; Latzin, Philipp ; Schmidt, Anne ; Schieck, Maximilian ; Toncheva, Antoaneta A. ; Michel, Sven ; Gaertner, Vincent D. ; Kabesch, Michael ; Frey, Urs


Background: Exhaled nitric oxide (eNO) is a biomarker of airway inflammation and seems to precede respiratory symptoms, such as asthma, in childhood. Identifying genetic determinants of postnatal eNO levels might aid in unraveling the role of eNO in epithelial function or airway inflammation and disease. Objective: We sought to identify genetic determinants of early postnatal eNO levels and ...


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