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Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT

Neuenhahn, M ; Albrecht, J ; Odendahl, M ; Schlott, F ; Dössinger, G ; Schiemann, M ; Lakshmipathi, S ; Martin, K ; Bunjes, D ; Harsdorf, S ; Weissinger, E M ; Menzel, H ; Verbeek, M ; Uharek, L ; Kröger, N ; Wagner, E ; Kobbe, G ; Schroeder, T ; Schmitt, M ; Held, G ; Herr, W ; Germeroth, L ; Bonig, H ; Tonn, T ; Einsele, H ; Busch, D H ; Grigoleit, G U



Abstract

Cytomegalovirus (CMV) infection is a common, potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed prospectively the safety and efficacy of stem cell-donor-or third-party-donor-derived CMV-specific T cells for the treatment of persistent CMV infections after allo-HSCT in a phase I/IIa trial. Allo-HSCT patients with ...

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