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Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT

Neuenhahn, M, Albrecht, J, Odendahl, M, Schlott, F, Dössinger, G, Schiemann, M, Lakshmipathi, S, Martin, K, Bunjes, D, Harsdorf, S, Weissinger, E M, Menzel, H, Verbeek, M, Uharek, L, Kröger, N, Wagner, E, Kobbe, G, Schroeder, T, Schmitt, M, Held, G, Herr, W, Germeroth, L, Bonig, H, Tonn, T, Einsele, H, Busch, D H and Grigoleit, G U (2017) Transfer of minimally manipulated CMV-specific T cells from stem cell or third-party donors to treat CMV infection after allo-HSCT. Leukemia 31 (10), pp. 2161-2171.

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Other URL: http://doi.org/10.1038/leu.2017.16


Abstract

Cytomegalovirus (CMV) infection is a common, potentially life-threatening complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT). We assessed prospectively the safety and efficacy of stem cell-donor-or third-party-donor-derived CMV-specific T cells for the treatment of persistent CMV infections after allo-HSCT in a phase I/IIa trial. Allo-HSCT patients with ...

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Item type:Article
Date:2017
Institutions:Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie)
Identification Number:
ValueType
10.1038/leu.2017.16DOI
Keywords:ADOPTIVE TRANSFER; CYTOMEGALOVIRUS DISEASE; TRANSPLANTATION; RECONSTITUTION; IMMUNITY; RECIPIENTS; THERAPY; IMMUNOTHERAPY; MULTICENTER; LYMPHOCYTES;
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39727
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