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Epithelial Chloride Transport by CFTR Requires TMEM16A

Benedetto, Roberta ; Ousingsawat, Jiraporn ; Wanitchakool, Podchanart ; Zhang, Yong ; Holtzman, Michael J. ; Amaral, Margarida ; Rock, Jason R. ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF). TMEM16A (also known as anoctamin 1, ANO1) is thought to function as the Ca2+ activated secretory chloride channel independent of CFTR. Here we ...

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