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Epithelial Chloride Transport by CFTR Requires TMEM16A

Benedetto, Roberta, Ousingsawat, Jiraporn, Wanitchakool, Podchanart, Zhang, Yong, Holtzman, Michael J., Amaral, Margarida , Rock, Jason R., Schreiber, Rainer and Kunzelmann, Karl (2017) Epithelial Chloride Transport by CFTR Requires TMEM16A. Scientific Reports 7 (1).

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Other URL: http://doi.org/10.1038/s41598-017-10910-0

Dieser Artikel ist in einer Zeitschrift aus dem Directory of Open Access (DOAJ) publiziert.


Abstract

Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) is the secretory chloride/bicarbonate channel in airways and intestine that is activated through ATP binding and phosphorylation by protein kinase A, but fails to operate in cystic fibrosis (CF). TMEM16A (also known as anoctamin 1, ANO1) is thought to function as the Ca2+ activated secretory chloride channel independent of CFTR. Here we ...

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Item type:Article
Date:2017
Institutions:Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Karl Kunzelmann
Identification Number:
ValueType
10.1038/s41598-017-10910-0DOI
Keywords:TRANSMEMBRANE CONDUCTANCE REGULATOR; CYSTIC-FIBROSIS; FLUID SECRETION; HCO3-SECRETION; MOUSE AIRWAYS; CA2+ SIGNALS; CHANNEL; CAMP; CELLS; ACTIVATION;
Dewey Decimal Classification:500 Science > 570 Life sciences
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:39764
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