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A Novel Metabolic Signature To Predict the Requirement of Dialysis or Renal Transplantation in Patients with Chronic Kidney Disease

Zacharias, Helena ; Altenbuchinger, Michael ; Schultheiss, U. T. ; Samol, Claudia ; Kotsis, F. ; Poguntke, I. ; Sekula, P. ; Krumsiek, J. ; Kottgen, A. ; Spang, Rainer ; Oefner, Peter J. ; Gronwald, Wolfram


Identification of chronic kidney disease patients at risk of progressing to end-stage renal disease (ESRD) is essential for treatment decision-making and clinical trial design. Here, we explored whether proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma improves the currently best performing kidney failure risk equation, the so-called Tangri score. Our study cohort comprised ...


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