Phenalen-1-one-Mediated Antimicrobial Photodynamic Therapy: Antimicrobial Efficacy in a Periodontal Biofilm Model and Flow Cytometric Evaluation of Cytoplasmic Membrane Damage

URN to cite this document:: urn:nbn:de:bvb:355-epub-401275
DOI to cite this document:: 10.5283/epub.40127

Cieplik, Fabian

; Steinwachs, Viktoria-Sophia ; Muehler, Denise ; Hiller, Karl-Anton ; Thurnheer, Thomas ; Belibasakis, Georgios N. ; Buchalla, Wolfgang ; Maisch, Tim

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Date of publication of this fulltext: 30 Apr 2019 07:38

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Abstract

In light of increasing resistance toward conventional antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a valuable alternative, especially for use in dentistry. In this regard, photosensitizers (PS) based on a phenalen-1-one structure seem to be especially favorable due to their high singlet oxygen quantum yield. However, the actual target structures of ...