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Phenalen-1-one-Mediated Antimicrobial Photodynamic Therapy: Antimicrobial Efficacy in a Periodontal Biofilm Model and Flow Cytometric Evaluation of Cytoplasmic Membrane Damage

Cieplik, Fabian, Steinwachs, Viktoria-Sophia, Muehler, Denise, Hiller, Karl-Anton, Thurnheer, Thomas, Belibasakis, Georgios N., Buchalla, Wolfgang and Maisch, Tim (2018) Phenalen-1-one-Mediated Antimicrobial Photodynamic Therapy: Antimicrobial Efficacy in a Periodontal Biofilm Model and Flow Cytometric Evaluation of Cytoplasmic Membrane Damage. Frontiers in Microbiology 9 (688), pp. 1-13.

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Date of publication of this fulltext: 30 Apr 2019 07:38

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Other URL: http://doi.org/10.3389/fmicb.2018.00688


Abstract

In light of increasing resistance toward conventional antibiotics and antiseptics, antimicrobial photodynamic therapy (aPDT) may be a valuable alternative, especially for use in dentistry. In this regard, photosensitizers (PS) based on a phenalen-1-one structure seem to be especially favorable due to their high singlet oxygen quantum yield. However, the actual target structures of ...

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Item type:Article
Date:6 April 2018
Institutions:Medicine > Lehrstuhl für Zahnärztliche Prothetik
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fmicb.2018.00688DOI
Keywords:biofilm, periodontal, photodynamic, phenalen-1-one, chlorhexidine, flow cytometry, propidium iodide, cytoplasmic membrane
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40127
Owner only: item control page

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