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Effects of the Highly COX-2-Selective Analgesic NSAID Etoricoxib on Human Periodontal Ligament Fibroblasts during Compressive Orthodontic Mechanical Strain

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Kirschneck, Christian ; Küchler, Erika Calvano ; Wolf, Michael ; Spanier, Gerrit ; Proff, Peter ; Schröder, Agnes
Date of publication of this fulltext: 30 Apr 2019 10:55


Human periodontal ligament (hPDL) fibroblasts play a major role during periodontitis and orthodontic tooth movement, mediating periodontal inflammation, osteoclastogenesis, and collagen synthesis. The highly COX-2-selective NSAID etoricoxib has a favorable systemic side effect profile and high analgesic efficacy, particularly for orthodontic pain. In this in vitro study, we investigated possible ...


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