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Light-Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum

Rustler, Karin ; Pockes, Steffen ; König, Burkhard


The histamine H-1 G protein-coupled receptor (GPCR) plays an important role in allergy and inflammation. Existing drugs that address the H-1 receptor differ in their chemical structure, pharmacology, and side effects. Light-controllable spatial and temporal activity regulation of photochromic H-1 ligands may contribute to a better mechanistic understanding and the development of improved ...


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