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Light-Switchable Antagonists for the Histamine H1Receptor at the Isolated Guinea Pig Ileum

Rustler, Karin , Pockes, Steffen and König, Burkhard (2019) Light-Switchable Antagonists for the Histamine H1Receptor at the Isolated Guinea Pig Ileum. ChemMedChem.

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Abstract

The histamine H1 G protein-coupled receptor (GPCR) plays an important role in allergy and inflammation. Existing drugs that address the H1 receptor differ in their chemical structure, pharmacology, and side effects. Light-controllable spatial and temporal activity regulation of photochromic H1 ligands may contribute to a better mechanistic understanding and the development of improved ...

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Item type:Article
Date:2019
Institutions:Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz)
Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König
Projects:GRK 1910, Graduiertenkolleg "Medicinal Chemistry of Selective GPCR Ligands"
Identification Number:
ValueType
10.1002/cmdc.201800815DOI
30628180PubMed ID
Keywords:azobenzene · GPCRs · histamine · organ pharmacology · photopharmacology
Dewey Decimal Classification:500 Science > 540 Chemistry & allied sciences
600 Technology > 615 Pharmacy
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40160
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