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Modulation of TMEM16 proteins: a novel therapeutic approach to Cystic Fibrosis therapy

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Benedetto, Roberta
Date of publication of this fulltext: 25 Jun 2019 08:13

Abstract (English)

Cystic Fibrosis (CF) is caused by mutations in the gene encoding the CF transmembrane conductance regulator (CFTR) protein. CFTR is the apical cAMP activated Cl- channel of epithelial cells. Mutations of this protein cause disruption of the electrolyte balance, leading to the formation of thick and sticky mucus in the lungs, and a variety of other problems. Cystic Fibrosis is a multifaceted ...


Translation of the abstract (German)

Mukoviszidose (Zystische Fibrose, Cystic Fibrosis, CF) wird durch Mutationen im CFTR (Cystic Fibrosis Transmembrane Conductance Regulator) Gen verursacht. CFTR ist der apikale cAMP-aktivierte Cl- Kanal in Epithelzellen. Mutationen im CFTR Protein führen zu einer Störung des Elektrolyttransports, was zur Bildung von hochviskösem und adhäsivem Schleim in Lunge und Darm sowie zu einer Vielzahl von ...


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