Potential Use of Gluconate in Cancer Therapy

URN to cite this document:: urn:nbn:de:bvb:355-epub-404647
DOI to cite this document:: 10.5283/epub.40464

Mycielska, Maria E. ; Mohr, Markus T. J. ; Schmidt, Katharina Maria ; Drexler, Konstantin ; Rümmele, Petra ; Haferkamp, Sebastian ; Schlitt, Hans J.

; Gaumann, Andreas ; Adamski, Jerzy ; Geissler, Edward K.

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Date of publication of this fulltext: 04 Jul 2019 10:50

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Abstract

We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is ...