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Potential Use of Gluconate in Cancer Therapy

Mycielska, Maria E., Mohr, Markus T. J., Schmidt, Katharina, Drexler, Konstantin, Rümmele, Petra, Haferkamp, Sebastian, Schlitt, Hans J., Gaumann, Andreas, Adamski, Jerzy and Geissler, Edward K. (2019) Potential Use of Gluconate in Cancer Therapy. Frontiers in Oncology 2019 (9), pp. 1-7.

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Date of publication of this fulltext: 04 Jul 2019 10:50

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Other URL: http://doi.org/10.3389/fonc.2019.00522


Abstract

We have recently discovered that cancer cells take up extracellular citrate through plasma membrane citrate transporter (pmCiC) and advantageously use citrate for their metabolism. Citrate uptake can be blocked with gluconate and this results in decreased tumor growth and altered metabolic characteristics of tumor tissue. Interestingly, gluconate, considered to be physiologically neutral, is ...

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Item type:Article
Date:19 June 2019
Institutions:Medicine > Lehrstuhl für Chirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3389/fonc.2019.00522DOI
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40464
Owner only: item control page

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