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Next Generation DNA-Seq and Differential RNA-Seq Allow Re-annotation of the Pyrococcus furiosus DSM 3638 Genome and Provide Insights Into Archaeal Antisense Transcription

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Grünberger, Felix ; Reichelt, Robert Martin ; Bunk, Boyke ; Spröer, Cathrin ; Overmann, Jörg ; Rachel, Reinhard ; Grohmann, Dina ; Hausner, Winfried
Date of publication of this fulltext: 25 Jul 2019 06:45


Pyrococcus furiosus DSM 3638 is a model organism for hyperthermophilic archaea with an optimal growth temperature near 100 degrees C. The genome was sequenced about 18 years ago. However, some publications suggest that in contrast to other Pyrococcus species, the genome of P. furiosus DSM 3638 is prone to genomic rearrangements. Therefore, we re-sequenced the genome using third generation ...


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