Color coded perfusion imaging with contrast enhanced ultrasound (CEUS) for post-interventional success control following trans-arterial chemoembolization (TACE) of hepatocellular carcinoma

URN to cite this document:

urn:nbn:de:bvb:355-epub-405711 Copy

DOI to cite this document:

10.5283/epub.40571 Copy

Rennert, Janine ; Wiesinger, Isabel ; Schicho, Andreas ; Beyer, Lukas Philip ; Wiggermann, Philipp ; Stroszczynski, Christian ; Jung, Ernst Michael

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Date of publication of this fulltext: 25 Jul 2019 07:55

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Details

Item type:	Article
Open Access Type:	Gold (with APC)
Höhe Gebühr (aus OpenAPC):	1713.66
Institution der Zahlung:	Regensburg U
Journal or Publication Title:	PLOS ONE
Publisher:	PLOS
Place of Publication:	SAN FRANCISCO
Volume:	14
Number of Issue or Book Chapter:	6
Page Range:	e0217599
Date:	10 June 2019
Institutions:	Medicine > Lehrstuhl für Röntgendiagnostik
Projects (Historical):	Open Access Publizieren (DFG)
Identification Number:	Value Type 10.1371/journal.pone.0217599 DOI
Keywords:	CLINICAL-PRACTICE GUIDELINES; LIVER-TRANSPLANTATION; MANAGEMENT; ABLATION; EFFICACY; COHORT;
Dewey Decimal Classification:	600 Technology > 610 Medical sciences Medicine
Status:	Published
Refereed:	Yes, this version has been refereed
Created at the University of Regensburg:	Yes
Item ID:	40571

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Abstract

Aim Evaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC. Material and methods 31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent superselective TACE using DSM Beads between 01/2015 and 06/2018. All patients underwent CEUS by an ...

Abstract

Aim Evaluation of an external color coded perfusion quantification software with CEUS for the post-interventional success control following TACE in patients with HCC. Material and methods 31 patients (5 females, 26 males, age range 34-82 years, mean 66.8 years) with 59 HCC lesions underwent superselective TACE using DSM Beads between 01/2015 and 06/2018. All patients underwent CEUS by an experienced examiner using a convex multifrequency probe (1-6 MHz) within 24 hours following TACE to detect residual tumor tissue. Retrospective evaluation using a perfusion quantification software regarding pE, TTP, mTT, Ri and WiAUC in the center of the lesion, the margin and surrounding liver. Results In all lesions, a post-interventional visual reduction of the tumor microvascularization was observed. Significant differences between center of the lesion vs. margin and surrounding liver were found regarding peak enhancement (867.8 +/- 2416 center vs 2028 +/- 3954 margin p< 0.005) and center 867.8 +/- 2416 vs 2824 +/- 4290 surrounding liver, p<0.0001)). However, no significant differences were found concerning Ri, WiAuC, mTT and TTP. Conclusion CEUS with color-coded perfusion imaging is a valuable supporting tool for post-interventional success control following TACE of liver lesions. Peak enhancement seems to be the most valuable parameter.

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Metadata last modified: 20 Jan 2025 14:46

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