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Short telomeres correlate with a strong induction of cellular senescence in human dental follicle cells

Morsczeck, Christian , Reck, Anja and Reichert, Torsten E. (2019) Short telomeres correlate with a strong induction of cellular senescence in human dental follicle cells. BMC Molecular and Cell Biology 20 (1), pp. 1-6.

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Date of publication of this fulltext: 05 Aug 2019 14:04

at publisher (via DOI)

Other URL: http://doi.org/10.1186/s12860-019-0185-4


Abstract

Background Dental follicle cells (DFCs) are dental stem cells and interesting options for regenerative therapies in dentistry. However, DFCs acquire replicative senescence in long-term cultures, but little is known about molecular processes. In previous studies, we observed that DFC cell lines become senescent at different rates. We hypothesized that short telomere length and increased DNA ...

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Item type:Article
Date:3 April 2019
Institutions:Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.1186/s12860-019-0185-4DOI
Keywords:Dental follicle cells, Cellular senescence, DNA damage, Telomere length
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40634
Owner only: item control page

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