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Short telomeres correlate with a strong induction of cellular senescence in human dental follicle cells

URN to cite this document:
urn:nbn:de:bvb:355-epub-406346
DOI to cite this document:
10.5283/epub.40634
Morsczeck, Christian ; Reck, Anja ; Reichert, Torsten E.
Date of publication of this fulltext: 05 Aug 2019 14:04



Abstract

Background: Dental follicle cells (DFCs) are dental stem cells and interesting options for regenerative therapies in dentistry. However, DFCs acquire replicative senescence in long-term cultures, but little is known about molecular processes. In previous studies, we observed that DFC cell lines become senescent at different rates. We hypothesized that short telomere length and increased DNA ...

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