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Contribution of Anoctamins to Cell Survival and Cell Death

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Kunzelmann, Karl ; Ousingsawat, Jiraporn ; Benedetto, Roberta ; Cabrita, Ines ; Schreiber, Rainer
Date of publication of this fulltext: 06 Aug 2019 15:13


Before anoctamins (TMEM16 proteins) were identified as a family of Ca2+-activated chloride channels and phospholipid scramblases, the founding member anoctamin 1 (ANO1, TMEM16A) was known as DOG1, a marker protein for gastrointestinal stromal tumors (GIST). Meanwhile, ANO1 has been examined in more detail, and the role of ANO1 in cell proliferation and the development of different types of ...


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