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Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis

Pattappa, Girish , Schewior, Ruth, Hofmeister, Isabelle, Seja, Jennifer, Zellner, Johannes, Johnstone, Brian, Docheva, Denitsa and Angele, Peter (2019) Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis. Cells 8 (8), p. 936.

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Date of publication of this fulltext: 18 Sep 2019 09:52

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Other URL: http://doi.org/10.3390/cells8080936


Abstract

Osteoarthritis (OA) is a degenerative condition that involves the production of inflammatory cytokines (e.g., interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)) that stimulate degradative enzymes, matrix metalloproteinases (MMPs) and aggrecanases (ADAMTS) resulting in articular cartilage breakdown. The presence of interleukin-1β (IL-1β) is one reason for poor ...

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Item type:Article
Date:20 August 2019
Institutions:Medicine > Lehrstuhl für Unfallchirurgie
Projects:Open Access Publizieren (DFG)
Identification Number:
ValueType
10.3390/cells8080936DOI
Keywords:cartilage; mesenchymal stem cells; chondrogenesis; hypoxia; interleukin-1ß; early osteoarthritis
Dewey Decimal Classification:600 Technology > 610 Medical sciences Medicine
Status:Published
Refereed:Yes, this version has been refereed
Created at the University of Regensburg:Yes
Item ID:40715
Owner only: item control page

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