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Physioxia Has a Beneficial Effect on Cartilage Matrix Production in Interleukin-1 Beta-Inhibited Mesenchymal Stem Cell Chondrogenesis

URN to cite this document:
urn:nbn:de:bvb:355-epub-407150
Pattappa, Girish ; Schewior, Ruth ; Hofmeister, Isabelle ; Seja, Jennifer ; Zellner, Johannes ; Johnstone, Brian ; Docheva, Denitsa ; Angele, Peter
Date of publication of this fulltext: 18 Sep 2019 09:52


Abstract

Osteoarthritis (OA) is a degenerative condition that involves the production of inflammatory cytokines (e.g., interleukin-1β (IL-1β), tumour necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6)) that stimulate degradative enzymes, matrix metalloproteinases (MMPs) and aggrecanases (ADAMTS) resulting in articular cartilage breakdown. The presence of interleukin-1β (IL-1β) is one reason for poor ...

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